Product Name :
SFRS3 Recombinant Rabbit Monoclonal Antibody [JE46-44]
Predicted band size :
Observed band size :
Synonyms:
arginine/serine-rich 3 antibody Pre mRNA splicing factor SRP20 antibody Pre-mRNA-splicing factor SRP20 antibody Serine/arginine-rich splicing factor 3 antibody Splicing factor antibody Splicing factor arginine/serine rich 20 kD antibody Splicing factor arginine/serine rich 3 antibody SRp20 antibody SRSF3 antibody SRSF3_HUMAN antibody 展开
Function :
Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human SFRS3 aa 34-83 / 164.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, IF-Cell
Coupling :
unconjugated
Clone number:
JE46-44
RRID:
AB_3070933
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.3,5,6-trichloro-1,2,4-triazine Chemscene
Subtype:
IgG
Purification method :
Protein A affinity purified.1,3,6,8-Tetrabromopyrene structure
ELTSA :
Molecular weight :
Predicted band size: 19 kDa
Positive control :
Mouse testis tissue lysate, rat brain tissue lysate, A431 cell lysate, SH-SY-5Y cell lysate, SiHa cell lysate, 293 cell lysate, Hela cell lysate, HepG2 cell lysate, A549 cell lysate, rat brain tissue, human colon tissue, human breast cancer tissue, human kidney tissue, mouse testis tissue, MG-63.PMID:33455561