Product Name :
2-Aminoisobutyric acid (CAS 62-57-7)
Synonym :
α-Aminoisobutyric acid
Application :
2-Aminoisobutyric acid is a functional component in the alanine cycle
CAS:
62-57-7
Purity:
≥99%
Molecular Weight:
103.12
Formula :
C4H9NO2
Physical state:
Solid
solubility :
Soluble in water (50 mg/ml), and alcohol (difficultly soluble). Insoluble in ether.
Shipping Condition :
Store at room temperature
Melting point:
≥300° C(lit.1421312-00-6 Chemscene )
SMILES:
CC(C)(N)C(O)=O
References:
:Solid-state conformation of a hybrid tripeptide between beta-amino acid; 8-aminocyclooct-4-enecarboxylic acid and 2-aminoisobutyric acid.165894-07-5 Price | Tanaka, M., et al. 2001. Chem Pharm Bull (Tokyo). 49: 1178-81. PMID: 11558607Characterization of sodium-dependent amino acid transport activity during liver regeneration. | Fowler, FC., et al. 1992. Hepatology. 16: 1187-94. PMID: 1427657Stimulus-secretion coupling of arginine-induced insulin release. Effect of 2-aminoisobutyric acid upon ornithine decarboxylase activity and insulin secretion. | Sener, A., et al. 1989. Res Commun Chem Pathol Pharmacol. 65: 65-80. PMID: 2506616Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid. | Tsuchiya, K. and Numata, K. 2017. Chem Commun (Camb). 53: 7318-7321. PMID: 28485427Quantification of 2-aminoisobutyric acid impurity in enzalutamide bulk drug substance using hydrophilic interaction chromatography with fluorescence detection. | Douša, M. 2019. J Pharm Biomed Anal. 164: 296-301. PMID: 30412802Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery. | Misawa, T., et al. 2019. Chem Commun (Camb). 55: 7792-7795. PMID: 31210205In vitro glucose and 2-aminoisobutyric acid uptake by rat interscapular brown adipose tissue. | Zamora, F., et al. 1988. Biochim Biophys Acta. 968: 346-52. PMID: 3278746Automated solid-phase concatenation of Aib residues to form long, water-soluble, helical peptides. | Zieleniewski, F.PMID:33529122 , et al. 2020. Chem Commun (Camb). 56: 12049-12052. PMID: 32902536Changes in 2-aminoisobutyric acid and cycloleucine uptake produced by 2,4-dichlorophenoxyacetic acid in Chinese hamster ovary cells. | Bergesse, JR., et al. 1987. Toxicol Lett. 36: 189-96. PMID: 3576650The accumulation of 2-aminoisobutyric acid in the costal and lumbar parts of the phrenectomized rat diaphragm in vitro. | Mamatas, SC. and Oja, SS. 1987. Acta Physiol Scand. 130: 201-7. PMID: 3604710Transport of 2-aminoisobutyric acid in cultured endothelial cells. | Lau, YT., et al. 1994. Biochim Biophys Acta. 1194: 118-22. PMID: 8075124The effect of retinoic acid on amino acid uptake and protein synthesis by lung fibroblasts. | Krupsky, M., et al. 1993. J Biol Chem. 268: 23283-8. PMID: 8226851Phenobarbital transiently stimulates uptake of 2-aminoisobutyric acid in hepatocytes. | Leibold, E. and Schwarz, LR. 1996. Arch Toxicol. 70: 368-72. PMID: 8975636